Surface Antigen Synthesis During the Progression of Hepatitis B Virus Tumorigenesis
Hepatitis B virus (HBV) infection has been recognized as a major risk factor for the development of
hepatocellular carcinoma. Several mechanisms have been proposed to explain HBV related
hepatocarcinogenesis, including insertional mutagenesis of HBV genomes, inflammation, regeneration, and
transactivating functions of HBV gene products, such as X protein and truncated middle surface protein.