The Correlation between Serum Activin A and Sepsis and Its Prognostic Value

  • Peng Wang
Keywords: Sepsis, Prognosis, Serum Activator A, ROC Curve

Abstract

To analyze the correlation between serum activin A and sepsis and its prognostic value. The data of 198 sepsis patients
treated in our hospital from January 2016 to January 2018 were analyzed and divided into death group (n=40 cases)
and survival group (n=158 cases). The age, sex and basic diseases of the two groups were compared, and the acute
physiology and chronic diseases of the two groups were compared. Acute Physiology and Chronic Health Evaluation
(APACHE II), Sequential Sepsis Related Organ Failure Assessment (SOFA) and Hematological Indicators were
compared. Multivariate Logistic Regression Analysis was used to analyze the factors affecting the prognosis of sepsis
patients. The diagnostic value and diagnostic efficacy of these factors in predicting the prognosis of sepsis patients
were evaluated by receiver operating characteristic curve (ROC curve). The scores of age, PCT, IL-6, ACT-A,
APACHE II and SOFA in the death group were significantly higher than those in the survival group (all P < 0.05).
There was no significant difference between the related indexes of combined basic diseases, WBC and sCr (all P >
0.05). APACHE II and SOFA scores were positively correlated with ACT-A levels (r = 0.683, 0.754). The results of
istic regression showed that age, PCT, IL-6, ACT-A level and APACHE II and SOFA scores were independent risk
factors for the prognosis of sepsis patients (all P < 0.05). ACT-A predicted the prognosis of sepsis patients with A UC
0.881 significantly higher than age and PCT (all P < 0.05). The best cut-off point for diagnosis was > 546.86pg/mL.
The sensitivity and specificity were 72.5% and 89.2% respectively. ACT-A has high diagnostic value and diagnostic
efficiency in predicting the prognosis of sepsis patients, and has high sensitivity and specificity. It can be used as an
indicator for clinical evaluation of the prognosis of sepsis patients.

Published
2019-09-15