Advances in the Study of Exosomes in Medical Insects and Vector- Borne Diseases

  • Peng Cheng
Keywords: Dengue Virus, Medical Insects, Vector-Borne Diseases, Immune System

Abstract

Exosomes are vesicles secreted by various cells in the body, which contain proteins, lipids and nucleic acids.
They play the roles of signal transduction, immune regulation, metabolite clearance and coagulation. Exosomes
may be an important link between cell-to-cell information transmissions. Complex information exchange
between medical insects and their hosts. Medical insects can transfer bioactive substances into host cells by
secreting exosomes. Regulate host immunity and mediate immune escape of medical insects. As drug carriers,
exosomes can block the transfer of medical insects in host cells or enhance the immunity of the host, providing
new opportunities for the prevention and treatment of medical insect diseases. In recent years, more and more
studies have found that exosomes also play an important role in the pathogenesis of pathogenic microbial
infectious diseases. Exosomes are small membranous vesicles originating from endocytosis secreted by most
cell types into extracellular space. Exosomes released from infected cells can mediate intercellular
communication to promote or regulate virus transmission. Dengue virus (DENV) is an arbovirus transmitted
from Aedes mosquitoes to humans. Interestingly, the role of exosomes during DENV infection in mammalian
cells has been described. However, little is known about exosomes from infected Drosophila cells. This paper
reviews the research progress of exosomes in medical insects and vector-borne diseases. The exosomes of
mesenchymal stem cells from Drosophila melanogaster can be collected in the medium. The exosomes of
mesenchymal stem cells from bone marrow can be identified by transmission electron microscopy, particle size
detection and flow cytometry. To study a method for isolation and identification of exosomes of Drosophila
melanogaster, and to provide experimental basis for further study of exosomes. It can provide new ideas for the
diagnosis and treatment of disease infection.

Published
2019-09-15