Surface Ultrastructure of Various Tumor Cells by Atomic Force Microscopic

  • Xiaomeng Zhang
Keywords: Tumor Cells, Ultra Microstructure, Atomic Force Microscopy, Morphological Characteristics


In recent years, with the development of nanomedicine and oncology molecular biology, more and more
attention has been paid to exploring the pathogenesis of cancer at the nanoscale and implementing new methods
and new technologies for diagnosis and treatment at the single cell and molecular level. Atomic force
microscopy (AFM) was initially used for nano-detection and characterization in the field of semiconductor
science and other materials. With the penetration of nano-technology and life science, especially the
development of nano-medicine, AFM has been successfully applied to the field of life science because of its
unique detection ability. This paper briefly introduces the development history of atomic force microscopy and
the engineering of atomic force microscopy, the working principles, working modes and imaging modes of
living cells in physiological states. Especially the research and application of biological atomic force
microscopy and high-speed atomic force microscopy in the field of biology. The continuous improvement of
scanning speed, scanning range and scanning accuracy of atomic force microscopy (AFM) will provide an
incessant impetus for the study of cancer cytology. This paper focuses on the research progress of atomic force
microscopy (AFM) in the field of cancer , including the research status of the surface ultrastructure,
morphological characteristics, hardness and viscoelasticity of tumor cells, and the application prospects of AFM
in cancer diagnosis and research and development of anti-cancer drugs are prospected.