Correlation between PD-L1 Protein and Ki-67 and Clinicopathological Features in Glioma Patients

  • Shengxiang Wu
Keywords: Glioma Patients, PD-L1 Protein, Ki-67 Expression, Pathological Characteristics

Abstract

As the incidence and mortality of gliomas continue to increase, the treatment of gliomas is expected to increase,
and the current research on glioma is not comprehensive. In order to deeply analyze the pathogenesis and
pathological features of glioma, this paper analyzed the pathological grades of PD-L1 in detail, and analyzed
PD-L1 and isocitrate dehydrogenase (IDH) mutations and different molecules, the relationship between typing
and the discovery that PD-L1 was mainly expressed in IDH-WT and interstitial patient specimens. The results
suggest that low expression or deletion of the tumor suppressor protein PTEN in human glioma may lead to high
expression of Ki-67, which increases the degradation of P27kip1, further confirming that Ki-67 may be
regulated by PTEN/PI3-K pathway, an important component of protein expression. In the experiment with the
degree of Schoenegger K peritumoral edema, the positive rate of Ki-67 expression in the edema group, mild
edema group and severe edema group were 57.14% (4/7) and 60% (6/10), 80.70% (46/57), the positive rate of
expression increased gradually. The overall difference was statistically significant (H=6.478, P=0.039), and the
positive expression rate of Ki-67 protein in Spearman rank correlation analysis the degree of edema around the
glioma was increased (r = 0.256, P = 0.028).

Published
2019-09-15