Comparison between Dexmedetomidine and Propofol on the Inflammatory Responses in Elderly Patients Undergoing Radical Gastrectomy

  • Dandan Feng
Keywords: Dexmedetomidine, Gastric Cancer, Inflammatory Response, Postoperative Complications


The anti-inflammatory role of dexmedetomidine has been highlighted recently. Propanol is an intravenous anesthetic
agent which is employed widely in clinical practice. The purpose of the study was to compare the effects
of dexmedetomidine and propofol on inflammatory responses and post-operative recovery in elderly patients
undergoing radical gastrostomy. 40 adult patients undergoing radical gastrostomy were divided into Dexmedetomidine
(D) group and Propanol group (P) group of 20 each. Patients in the D group received bolus dose infusion
of dexmedetomidine (0.6μg/kg for 10 min) followed by a maintenance dose of 2.0μg/kg/h. Patients in the
P group received bolus dose of propofol (1mg/kg for 10 min) followed by a maintenance dose of 100ug/kg/min.
Hemodynamic parameters, biochemical data, catecholamine and cytokine levels were recorded and postoperative
complications were observed. The hemodynamics was found to be stable in group D. interleukin (IL)-
1β levels were significantly lower after extubation in group D and IL-6 levels were markedly lower after intubation
and estuation in group D. Tumour necrosis factor (TNF)-α level were similar in both groups. IL-10 levels
were markedly higher after intubation and estuation in group D. Catecholamine levels were increased significantly
in group P,Dexmedetomidine reduced the incidence of postoperative nausea, vomiting(PONV) and shivering,
and it did not prolong post anesthesia care unit(PACU) discharge time. Dexmedetomidine was comparable
with propofol in maintaining anesthesia. It may prevent inflammatory responses and suppress the stress
response without impacting on the patients’ hemodynamic stability.