Comparative Analysis of the Effects of Different Blood Purification Methods on Renal Anemia in Patients with End-Stage Renal Disease

  • Yayin Tan
Keywords: Blood Purification Methods, Renal Anemia, Hemodialysis, Hemodiafiltration, Hemoperfusion

Abstract

In order to explore the effect of different blood purification methods on renal anemia in patients with end-stage
renal disease (ESRD), 120 ESRD patients who underwent maintenance hemodialysis (MHD) treatment at
designated hospitals by this research from June 2013 to June 2018 were selected as study subjects, and were
divided into three groups according to the random number table method: routine hemodialysis (HD) group,
hemodiafiltration (HDF) group and hemoperfusion tandem hemodialysis (HP+HD) group with 40 cases in each
group. The patients in HD group only underwent hemodialysis alone, the patients in HDF group underwent
hemodialysis + hemodiafiltration, and the HP+HD patients underwent hemodialysis + hemoperfusion; the
subjects' hemoglobin (Hb), serum ferritin (SF), serum iron (SI), blood urea nitrogen (BUN), hematocrit (Hct),
electrolytes and other biochemical indicators as well as four macromolecular toxins of high-sensitivity
C-reactive protein (hs-CRP), intact parathyroid hormone (i-PTH), interleukin 6 (IL-6) and β2 microglobulin
(β2-MG) were tested respectively to evaluate the improvement of renal anemia in ESRD patients with different
blood purification methods. The results showed that after 3 months of treatment, hs-CRP and i-PTH in HP+HD
group were higher than those in HD group, β2-MG was higher than that of HD group and HDF group, and
i-PTH in HDF group was higher than that of HD group (P<0.05). After 6 months of treatment, the levels of
hs-CRP, β2-MG and i-PTH in HP+HD group and HDF group were higher than those in HD group, and the
levels of hs-CRP and β2-MG in HP+HD group were higher than those in HDF group (P<0.05), suggesting that
different blood purification treatments can correct the anemia of patients with renal failure to different degrees.
There were no statistically significant differences in the levels of Hb, Hct and BUN in the three groups before
treatment and after 6 months of treatment (P>0.05) while there were statistically significant differences between
the HDH group and the HDF group (P<0.05) after 12 months of treatment. After 12 months of treatment, Hb,
Hct and BUN levels in the HP+HD group and the HDF group were higher than those in the HD group, and the
Hb and Hct levels in the HP+HD group were higher than those in the HDF group (P<0.05). Through analysis, it
is believed that different blood purification methods have different effects on the improvement of renal anemia
in patients with end-stage renal disease and adding hemodiafiltration and hemoperfusion to routine hemodialysis
can reduce the accumulation of molecular toxins in the body and reduce the long-term dialysis complications.

Published
2019-09-15