Papillary Thyroid Carcinoma Concurrent with Hashimoto’s Thyroiditis: A Retrospective Analysis of 702 Patients
The objective of this study was researching a series of patients with papillary thyroid carcinoma (PTC) to evaluate the prevalence of concurrent Hashimoto’s thyroiditis (HT) and assess the prognosis and clinicopathological characteristics of PTC patients with or without HT. We collected all consecutive thyroid histopathological reports from October 2006 to October 2012 in Zhejiang Province Cancer Hospital to collected first-time diagnostic PTC patients. In total, 351 cases were affirmed as PTC with HT, otherwise a control group matched for age, gender, histology, and stage was used to evaluate disease progression and prognosis. The data we collected included surgical procedures, tumor staging, recurrence and metastasis, as well as basic pathological characteristics, such as the maximum diameter of the tumor, multifocality, and multicentricity. The mean ages of HT and non-HT cases at diagnosis were 43.30 years (range, 15-71 years; median, 44 years) and 43.32 years (range, 16-72 years; median, 44 years). We collected the pathological reports and analyzed the pathological data. Based on univariate analysis, the incidences of capsular/extracapsular invasion, neuro invasion, intrathyroidal dissemination were higher in the comparision group (p < 0.05). PTC with HT tended to be in an earlier stage of clinicopathology (p = 0.003). No statistically significant differences were found between the two groups in terms of surgical strategy, multifocality, multicentricity, vascular invasion, and M-staging (p > 0.05). HT is associated with an increased incidence of PTC. HT, however, seems to play a protective role in the progress of the PTC. The specific mechanism of PTC merging HT needs further study.