The Precise Mechanism for Oncogene Addiction in the Sustained Survival

  • Alfieri Ginestre

Abstract

A rapidly growing body of evidence now supports a role for oncogene addiction in the sustained survival and proliferative capacity of many if not all tumor cells. Multiple theories have been put forth, including genetic streamlining, signaling network dysregulation, synthetic lethality, and oncogenic shock. However, experimental evidence to prove or disprove these models is generally lacking. This research work proposes a new precise mechanism for oncogene addiction in the sustained survival

Published
2019-07-15